PhD course work syllabus semester-II
PhD course work syllabus semester-II

Semester-II

S. N.

Course

Title

Credit(s)

 

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

Compulsory

CHE-C-241

CHE-C-242

CHE-C-243

CHE-C-244

CHE-C-245

CHE-C-246

CHE-C-247

CHE-C-248

CHE-C-249

CHE-C-250

 

Structural Inorganic Chemistry and Radio-chemistry

Advanced heterocyclic synthesis and its applications

Kinetics and Mechanism of Chemical Transformation

Applied Electrochemistry

Laboratory Course in Structural Inorganic Chemistry and Radio-chemistry

Laboratory Course in Advanced heterocyclic synthesis and its applications

Laboratory Course in Kinetics and Mechanism of Chemical Transformation

Laboratory Course in Applied Electrochemistry

Project work on proposed research topic and synopsis of the thesis

Seminar and viva-voce examination on above (2+2)

 

3

3

3

3

1

1

1

1

4

4

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CHE-C-241

 Structural Inorganic Chemistry and Radio-chemistry

                         L-3, T-0, P-0, C-3                                                                    45 Hours

                                   

1. Preparative Inorganic Chemistry: Kinetics and thermodynamic aspect of synthesis; Basic Techniques (Low temp., High temp., High pressure, Vacuum line, Inert atm.  etc, devices). Electrolytic, electrostatic discharge, Photochemical & Microwave assisted synthesis; Role of solvents in synthesis & crystallization; Uses of Chromatographic techniques in synthesis; Some selected Inorganic synthesis; Growing Crystals from Solutions.

2. Structure/ Characterization from Chemical data: Microanalysis, magnetic measurements, mass spectrometry, electronic spectra, optical activity, i.r., Raman, esr, nmr, X-ray (diffraction & single crystal), electron diffraction, Photoelectron spectroscopy, probing surface & size  using SEM , TEM & XRD; application of electrometric and thermal  techniques.

3. Application of Inorganic compounds in: (a) Homogeneous & Heterogeneous catalysis, (b) Bioinorganic Chemistry.

4. Coordination and stereochemistry, Chemistry of Ac,Th and U, Identification and uses of elements beyond Uranium; Super heavy elements. Nuclear synthesis of Trans-uranium elements; Nuclear reaction theory; Types of nuclear reactions; Nuclear power reactors; Safety features of reactors;

5. processing of spent nuclear fuel; Radioactive waste management- Sources, Processing, Causes and Effects; Treatment, Storage and Disposal; Hazards and Safety measures.

6. Radiation Chemistry and Radiation Biology: Primary radiation effect, Radiation dosimetry, radiolysis, Intermediates (ions, excited molecules, free radicals), Radiation chemistry in different media, Radiation in chemical processes, Industrial applications of Radiation and Health processes. Nuclear medicines and diagnostics.

Course-in-charge: Prof A.P.Mishra

 

 

CHE-C-242

Advanced Heterocyclic Synthesis and its Applications

L-3, T-0, P-0, C-3                                                                     45 Hours

 

I.

General Introduction

I.1.

Organic synthesis by conventional, microwave, ultrasonic, electro-organic and PTC based synthesis and relation to green chemistry.

I.2.

General idea of main heterocyclic molecules with chemistry and biochemistry of present functional groups.

I.3.

Comparative study and advantages of these techniques.

II.

Synthesis of azetidinones (b-lactams ring)

II.1a.

Introduction

II.1b.

Nomenclature of azetidinones and interaction with other molecules

II.1c.

Thermodynamic aspects

II.1d.

Stereochemical aspects

II2a

Reactivity and mechanisms on heteroatom

II.2b.

Thermal and Photochemical reactions

II.2c.

Electrophilic substitution

II.2d.

Nucleophilic substitution

II.2e.

Cycloaddition reactions

II.3a.

Synthetic procedures

II.3b.

Synthesis by condensation

II.3c.

Synthesis by cycloaddition

II.3d.

Various bond formation

II.3e.

Cyclization and ring transformation

II.4a.

Characterization by spectroscopic techniques (IR, NMR, Mass, X-rays, UV, HPLC, TLC etc.)

II.4b.

Pharmaceutical and clinical applications of various b-lactams.

III.

Synthesis of Thiadiazoles

III.1a.

Introduction of various thiadiazoles

III.1b.

Nomenclature of thiadiazoles

III.1c.

Physical aspects of thiadiazoles

III.1d.

Stereochemical aspects of thiadiazoles

III.2a.

Reactivity and mechanisms

III.2b.

Thermal and Photochemical reactions

III.2c.

Electrophilic reaction

III.2d.

Nucleophilic reaction

III.2e.

Reactions with radicals and electron-deficient species.

III.2f.

Cycloaddition reactions

III.2g.

Reactions of substituents on methylene group

III.3a.

Synthetic procedures

III.3b.

Formation of one bond, two and three bond with cyclizations and dipolar cycloadditions.

III.3c.

Formation by ring transformations

III.4a.

Characterization by spectroscopic techniques (IR, NMR, Mass, X-rays, UV, HPLC, TLC etc.)

III.4b.

Pharmaceutical and clinical applications of various Thiadiazole nucleus.

IV.

Synthesis of thiazolidenes and their 5-arylidene derivatives

IV.1a.

Introduction of thiazolidenes

IV.1b.

Nomenclature of thiazolidenes

IV.1c.

Physical aspects of thiazolidenes

IV.1d.

Stereochemical aspects of thiazolidenes

IV.2a.

Reactivity and chemistry

IV.2b.

Electrophilic substitution

IV.2c.

Nucleophilic substitution

IV.2d.

Knovenzal reaction

IV.3a.

Synthetic procedures

IV.3b.

Cyclization procedures – formation of 3,4-bond and 2, 3-bond

IV.3c.

5-substitution

IV.4a.

Characterization by spectroscopic techniques (IR, NMR, Mass, X-rays, UV, HPLC, TLC, etc.)

IV.4b.

Pharmaceutical and clinical applications of various thiazolidenes and their 5-arylidenes

 

 

 

Books Suggested

1.

Goodman and Gillman. The Pharmacological basis of therapeutics, McGraw Hill, 1996.

2.

Katritzky, A.R. and Rees, C.W., Comprehensive Heterocyclic Chemistry Pergamon Press, N. York.

3.

Katritzky, A.R. and Pozharskil H. and Book of Heterocyclic Chemistry, 2nd Ed. Pergamon Press, 2000, New York.

4.

Gupta, R.R., Vol. I and II, Heterocyclic Chemistry Sprinzer Verlap.

5.

Comprehensive Heterocyclic Chemistry Vol. 6 by Katritzky and Rees.

6.

George R. Newkome and Asutosh Nayak.

7.

Heterocyclic Chemistry and Introduction, A. Albert, 2nd Ed., Athlone Press, London.

8.

Physical Methods in Heterocyclic Chemistry, Vol. III and IV, Academic Press, New York.

9.

The Structure and Reactions and Heterocyclic Compounds M.H. Palmer Edward Arnold London.

10.

Dehmlow, E.V., Dehmlow S.S., PTC Third revised and enlarged Edition.

11.

Burger’s Medicinal Chemistry, Vol. I-V.

12.

Various Journals viz. J. Med. Chem. Ind. J. Chem., Tetrahedron, Tetrahedron letters, J. Med. Chem., Organic Letters, European Journal of Medicinal Chemistry, Heterocyclic Chemistry, Indian Chemical Society, etc.

 

 

 

Course Incharge: Professor S.K. Srivastava

Instructors: Professor S.D. Srivastava

                        Dr. (Mrs.) Ritu Yadav

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CHE-C-243

Kinetics and Mechanism of Chemical Transformation

L-3, T-0, P-0, C-3                                                                  45 Hours

 

                          

1.         Solution Kinetics

Frank – Robinowitch effect, Bronsted – Bjerrum equation, linear free energy relationship, Thermodynamics implications of linear free energy relationship. Hammett's equation, Taft equation. Effect of solvent on reaction rate.

2.         Catalytic reactions

Function of catalyst in terms of Gibbs's free energy of activation in chemical reactions, Effect of pH on reaction rate. Bronsted catalysis law and its equation. Acidity function, Heterogeneous catalysis, Langmuir-Hinshelwood mechanism, Kinetics of Heterogeneous reactions.   

3.         Drug Release Kinetics

The blood level curve, volume of distribution, types of drug release, reservoir type and a matrix type system.

Polymeric microspheres- Gelation Microspheres, Albumin Microspheres, Dextran Microspheres, Poly Lactide and Poly Glycolide Microspheres etc.

4.               Modeling of Drug Release-

         Korsmeyer –Peppas model, Moyes- Whitney theory, Nernst    and Brunner Film Theory.

5.               Release Kinetic Modelling

 

i)                    Statistical Methods- Explanotory data analysis method, repeated measures design, multivariate approach [ MANOVA, multivariate analysis of variance]

ii)                  Model dependent methods – zero order, first order, Higuchi Square root model, Korsmeyer Peppas model, Hixon Crowell model, Baker Lonsdale, Weibull model.

iii)                Model independent methods- difference factor, similarity factor, LOQ & LOD ( Limit of quaification and Limit of detection)

iv)                Hopfenberg model, Gompertz model.

6.      Regression model for drug Release Kinetics

Linear or first order regression model, Quadratic or Second order regression model, Non Linear regression model.

Course In-charge- Prof Archana Pandey

Course Instructor- Prof F. Khan

CHE-C-244

Applied Electrochemistry

               L-3, T-0, P-0, C-3                                                                  45 Hours

 

1.     Carbon based Electrode Materials: Material synthesis, fabrication and application of Carbon based electrode, Carbon paste electrode, Carbon nanotube (Single and Multi walled), Glassy Carbon electrode, glassy carbon fiber electrode etc.

2. Some Modern Electroanalytical Techniques : Principle and application of Anodic and Cathodic stripping voltammetry, Pseudo-polarography for speciation studies, Spectro-electrochemistry, Cyclic voltammetry.

3. Electrochemistry in Materials Science: Corrosion of Metals. Corrosion rate expression. Electrochemical aspect of polorization, Passivity. Forms of corrosion (Eight forms of Corrosion).

4. Corrosion Kinetics : Corrosion testing. Materials and specimens, Surface propagation, Gravimetric method, measuring and weighing, exposure techniques. Planned interval tests. Corrosion rate determination at short time intervals.

5. Corrosion of Metals and Alloys in different media. High Silicon Cast steel, other alloy cast steel. Carbon steel and iron, Low alloy steels. Corrosion of Al, Ni, Ph, Cu etc. and their alloys.

6. (i) Electrode modification: Fabrication and application of modified electrodes (Biomolecular modified, DNA, drugs, inorganic compounds etc modified) for analytical purposes and also for the study of mechanism of action of biomolecules, Types of electrode modification.

(ii) Enzyme Electrode: Electrodes carrying enzymes, The electrochemical enzyme catalysed oxidation of some organic compounds (styrene). Application of Enzyme modified electrode for the study of mechanism of action of drugs (Anticancer and other drugs).

7. Biosensor: Typical functions of biosensor. Electrochemical biosensor, Amperometric biopsensors. Potentiometric biosensors and impedimetric / conductometric biosensors, Electrochemical biosensors in chemotherapy.

Course In charge-   Prof. K.S. Pitre

CHE-C-245

Lab Course in Structural Inorganic Chemistry and  Radio-chemistry

L-0, T-0, P-3, C-1

 

1. Syntheses and characterization of some selected Inorganic Complexes.

2. Physico-chemical studies of Complexes of Th, U and some selected lanthanides.

3. Separation/estimation of some Lanthanide and Actinide ions (Two ion mixture) by solvent extraction/ion exchange/gravimetric methods.

4. Uses and application of available techniques /Instrumentation.

5. Interpretation of Spectra/Thermograms/Voltammograms/Chemical data

Course-in-charge: Prof  A.P.Mishra

 

 

 

 

 

 

 

 

 

 

 

 

 

CHE-C-246

Lab Course in Advanced Heterocyclic Synthesis and its Applications

L-0, T-0, P-3, C-1

 

I.a.

Synthesis of azetidinones, thiadiazole, and thiazolidene and their 5-arylidene heterocyclic molecules by applying conventional, microwave, ultrasonic, phase transfer catalysis, electroorganic based synthesis.

I.b.

Using one or more heterocyclic moiety

II.a.

Purification of products by chromatographic techniques.

II.b.

Characterization of the products by spectroscopic and chemical techniques.

III.a.

Determination of various physical parameters of the synthesized molecules

III.b.

Study their various possible stereoisomers of the synthesized molecules.

IV.a.

Biological significance of the compounds.

IV.b.

SAR Study of the synthesized compounds.

 

 

Course In charge- Prof S. K. Shrivastava

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CHE-C-247

Laboratory course in Kinetic of Mechanism of Chemical Transformation

L-0, T-0, P-3, C-1

 

 1. Determination of rate constant:

 (a) Determination of velocity constant and order of the reaction catalyzed by surfactants, oxides and sulfides.

 (b) Study the influence of medium i.e. dielectric constant, ionic strength.

2. Solubility of drugs:

Study the solubility of hydrophobic drugs in different solvents viz. distilled water, SLS, CTAB, PEG 400, and PVP 44000 by spectrophotometry, Turbidimetry, Nephelometry.

3. Drug Release

 (a) Study the drug dissolution as reported in pharmacopaea.

 (b) Study the drug dissolution in different media i.e. at different pH, buffers and polymeric surfactants.

4. Physico-chemical characterization of Drugs

The following chemical and physical properties of the drug will be studied by using computer software

(a) Surface area

(b) Dipole

(c) Molar volume

(d) Minimization energy

(e) Bond angle

(f) Bond Length

(g) Partial charge on active sites

(h) lipophilicity

(i) Drug release profile

 

Course Incharge- Prof Archana Pandey

 

CHE-C-248

Laboratory course in Applied Electrochemistry

L-0, T-0, P-3, C-1

 

1.      Use of following modern analytical techniques for the analysis of electroactive species (organic and inorganic), in synthetic samples and samples of natural, biological/ industrial origin.

Techniques:-

i.                    Differential pulse polarography / voltammetry

ii.                  Differential pulse anodic stripping / voltammetry

iii.                Differential pulse cathodic stripping / voltammetry

2.      Pseudo polarography for specification studies on sea water  (synthetic samples) for its Pb content.

3.      Gravimetric method for corrosion rate determination (brass in acidic and basic medium).

4.      Corrosion rate determination at short intervals using DPP/DPASV methods.

5.      Preparation of conducting polymers as polymer electrolytes and material for electrodes.

6.      Fabrication of DNA and anticancer drug modified electrodes as biosensors for analytical purposes.

 

Course Incharge- Prof K. S. Pitre